While writing a post for my chess blog on a young chess player
who reportedly died after taking a couple of shots of alcohol and
four Tylenol tablets for his cold, I was prompted to do some research on over the
counter drugs and alcohol, especially pain remedies containing
acetaminophen.
It turns out that combining acetaminophen pain relievers and
even light amounts of alcohol can more than double the risk of kidney
disease according to new research. Taking the recommended dose of
acetaminophen, combined with a small to moderate amount of alcohol,
produces a 123 percent increased risk of kidney disease according
preliminary studies. There appears to be a harmful interaction
between the drug and alcohol even in small amounts.
Chronic acetaminophen use and chronic alcohol abuse both have
been separately linked to kidney and liver disease, said Dr. Martin
Zand, medical director of the kidney and pancreas transplant programs
at the University of Rochester Medical Center in New York, so
combining the two can be very dangerous.
What has not been well-studied until now is the link between
some regular alcohol use and regular acetaminophen use and increasing
your risk of kidney disease above the risk of either if they are used
separately. It should be pointed out that a study conducted
by the U.S. National Health and Nutrition Examination Survey found
that neither normal use of acetaminophen nor light to moderate
drinking posed a potential threat to kidneys.
Alcohol can interfere
with the gene that regulates the way the body processes
acetaminophen. So, to be safe people who regularly use one
should not use the other. That begs the question, what about taking acetaminophen for a
hangover? The conclusion was that if you are not a regular drinker,
it would seem to be OK to take some acetaminophen.
Over the counter drugs are dangerous
to take with alcohol because it is possible that alcohol
interaction may decrease the effectiveness or render them useless. In
other cases, alcohol interactions may make drugs harmful or even
toxic to the body. Even in small amounts, alcohol also may intensify
medication side effects.
It's also important to remember that herbal remedies are not immune from the same warnings.
Manufacturers of herbal products are not required to submit proof of
safety and effectiveness to the U.S. Food and Drug Administration
before marketing, so the adverse effects and drug interactions
associated with herbal remedies are largely unknown.
Ginkgo biloba extract has been reported to cause spontaneous
bleeding and it may interact with anticoagulants and antiplatelet drugs. St. John's Wort may may cause increased levels of serotonin,
dopamine and norepinephrine and although it probably does not
interact with foods that contain tyramine, it should not be used with
prescription antidepressants.
Ephedrine-containing herbal products have been associated with
adverse cardiovascular events, seizures and even death. Ginseng,
widely used for its purported physical and mental effects, is
generally well tolerated, but it has been implicated as a
cause of decreased response to Warfarin.
Herbal products therefore cannot be marketed for the diagnosis,
treatment, cure or prevention of disease. However, these products can
legally be labeled with claims about their purported effects. Also, herbal products are not regulated for purity and potency
and some of the adverse effects and drug interactions reported for
herbal products could be caused by impurities, batch variations, etc.
When alcohol use is combined with some medications, it may
magnify problems, especially in older adults. Hundreds of commonly used prescription and over-the-counter
drugs may adversely interact with alcohol. A list can be found HERE.
The National Institute on Alcohol Abuse and Alcohol Addiction offers
a pamphlet on mixing alcohol with medications HERE.
While
on the subject of drug interactions, did you know that many foods and
supplements can interfere with blood pressure medicine? This article
from the American Heart Association may surprise you.
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